cees dekker - An Overview
cees dekker - An Overview
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Making use of single-molecule optical and AFM imaging and drive-spectroscopy tactics, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions contain:
1996, first mesoscopic cost density waves products; and first electrical measurements on an individual metallic nanocluster in between nanoelectrodes
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Our operate was immediately adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
This yielded a breakthrough. Within just just a few months, we were being capable to evaluate transport via someone single-walled carbon nanotube. Based upon reduced-temperature experiments by a superb PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft University of Technological innovation with an Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being real quantum wires with incredibly extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
‘At the beginning we looked at biological programs with a physical look at and acted on The premise of the resources we realized. It took a few years just before we started off working much more on the large Organic difficulties. I then began to call it nanobiology, a phrase that did not exist at enough time.
Nanopores represent an elegant and versatile tool to measure one molecules. We investigate novel detection modes with solid-point out nanopores as well as various approaches to measure proteins with nanopores. Tasks encompass the following:
‘You shouldn't just think about the questions of tomorrow, but also take into account the queries on the day soon after tomorrow’
Really interesting, but that wasn’t truly wherever my interest lay. I planned to pioneer And that i had the feeling which was now not possible, since the most appealing fundamental insights had previously been uncovered. But my industry had produced quite a few exciting new resources to evaluate unique molecules. I decided that I desired to implement this to biology, to have a look at it from the ceesdekker.net physical point of view.’
‘The idea that There is certainly this type of matter as being a starting, a giant bang, is by now a fascinating signpost to think about that there was a creator. But far more generally, and on The idea of pure rationality, I also get there in a Christian interpretation of truth. An atheistic worldview is a naturalistic worldview: fundamentally, you'll find only atoms and normal forces that we could evaluate.
‘That issues the artificial mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared best-down in All those days and determined about 5 hundred genes which are minimally demanded for any performing cell. We want to glance base-up: how do we transfer from the few molecules to a whole Organic procedure?
Allow’s 1st glance again at this time when you decided to change your concentration from superconductivity and nanotubes to biology at the conclusion of the nineteen nineties.
2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in nanofluidic channels; very first electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization from the mechanical Attributes of double-stranded RNA; and 1st single-molecule examine of DNA translocation by a restriction-modification enzyme.